Protein Details: Gap junction gamma-2 protein

Protein ID

ICDB_Pro_1219

Protein Name

Gap junction gamma-2 protein

Gene Name

Gjc2; Gja12

Organism

Mus musculus (Mouse)

Length

440 amino acids

AlphaFoldDB

AF-Q8BQU6-F1-model_v4.pdb

Function

Sequence

MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGTRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERAEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPTPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCAGLNATSRGAPRVGGLASGTGSATSGGTVGEQSRPGAQEQLATKPRAGSEKGSTGSRDGKATVWI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Mainly expressed by oligodendrocytes in the central nervous system (at protein level)

DOI ID

10.1523/jneurosci.21-04-01117.2001; 10.1126/science.1112014; 10.1016/j.ygeno.2004.11.007; 10.1523/jneurosci.23-11-04549.2003; 10.1523/jneurosci.23-13-05963.2003; 10.1016/j.neuroscience.2004.03.063; 10.1074/mcp.t500041-mcp200; 10.1016/j.cell.2010.12.001

RefSeq

NP_536702.3; NP_780661.2